| 发明名称 |
METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF .ALPHA.V.BETA.5 MEDIATED ANGIOGENESIS |
| 摘要 |
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin .alpha.v.beta.5 antagonists. The .alpha.v.beta.5-mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial growth factor, transforming growth factor-.alpha. and epidermal growth factor. Inhibition of .alpha.v.beta.5-mediated angiogenesis is particularly preferred in vascular endothelial ocular neovascular diseases, in tumor growth and in inflammatory conditions, using therapeutic compositions containing .alpha.v.beta.5 antagonists.
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| 申请公布号 |
CA2256588(A1) |
申请公布日期 |
1997.12.04 |
| 申请号 |
CA19972256588 |
申请日期 |
1997.05.30 |
| 申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
CHERESH, DAVID A.;FRIEDLANDER, MARTIN;BROOKS, PETER |
| 分类号 |
A61K45/00;A61K38/00;A61K38/04;A61K38/16;A61K38/48;A61K39/395;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P37/08;A61P43/00;C07C279/14;C07C311/06;C07C311/10;C07D263/38;C07K14/435;C07K14/705;C07K14/75;C07K14/78;C07K16/28;C07K19/00;C12N9/64;(IPC1-7):C12N9/64;C07K7/08;A61K38/10;A61K38/12;C07K5/12;A61K38/39;C07K7/64 |
主分类号 |
A61K45/00 |
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