发明名称 |
PEGylated mutated Clostridium botulinum toxin |
摘要 |
Modified botulinum toxin (BoNT) which exhibits a natural heavy chain and a modified light chain, where the light chain is modified at its N terminal end that exhibits a chain extension in the direction from the N- to the C-terminal end. Modified botulinum toxin (BoNT), which exhibits a natural heavy chain and a modified light chain, where the light chain is modified at its N terminal end that exhibits a chain extension in the direction from the N- to the C-terminal end, with a structure of (-(Cy) n-(tag) m-(X) l). Cy : cysteine residue, where at least one of the cysteine residues in the chain extension is coupled to at least a chain polyethylene glycol; tag : any tag, preferably histidine tag or streptavidin tag; X : any naturally occurring amino acid; n : 1-50; m : 0 or 1; and l : 0-50. Independent claims are included for: (1) a composition for human and/or veterinary medicine comprising the modified botulinum toxin; (2) a nucleic acid which codes for the modified botulinum toxin; (3) a vector comprising the nucleic acid; and (4) a host cell comprising the vector. ACTIVITY : Muscular-Gen; Neuroprotective; Muscle-Relaxant; Antiinflammatory; Gastrointestinal-Gen; Inotropic; Dermatological. MECHANISM OF ACTION : None given. |
申请公布号 |
EP1834962(A1) |
申请公布日期 |
2007.09.19 |
申请号 |
EP20060005300 |
申请日期 |
2006.03.15 |
申请人 |
BIOTECON THERAPEUTICS GMBH |
发明人 |
FREVERT, JUERGEN;SPECHT, VOLKER |
分类号 |
C07K14/33;A61K38/16;A61K47/48 |
主分类号 |
C07K14/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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