IDENTIFYING THE ANTIGENIC TARGET OF AUTOIMMUNE SENSORINEURAL HEARING LOSS (AISNHL) AND DEVELOPEMENT OF SPECIFIC TESTS FOR DIAGNOSIS AND MANAGEMENT OF AISNHL

摘要

The substantial purification and characterization of the glycoprotein Inner Ear Supporting Cell Antigen (IESCA) is described, along with methods employing IESCA to detect autoimmune sensorineural hearing loss (AISNHL), agonists and antagonists of IESCA binding and anti-IESCA binding, as well as homologs of IESCA.