发明名称 |
Derivatives of alkylpiperazine and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors |
摘要 |
The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of disease and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
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申请公布号 |
US7482346(B2) |
申请公布日期 |
2009.01.27 |
申请号 |
US20060466192 |
申请日期 |
2006.08.22 |
申请人 |
SANOFI-AVENTIS |
发明人 |
ABOUABDELLAH AHMED;ALMARIO GARCIA ANTONIO;HOORNAERT CHRISTIAN;LI TAK ADRIEN |
分类号 |
A61K31/50;A61K31/495;A61K31/496;A61K31/4965;A61K31/497;A61K31/501;A61K31/506;C07D209/16;C07D215/20;C07D215/26;C07D231/12;C07D239/26;C07D241/04;C07D243/08;C07D261/08;C07D277/28;C07D295/00;C07D295/185;C07D295/205;C07D401/00;C07D403/00 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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