Immobilized biologically active entities containing heparin having high biological activity following mechanical manipulation

摘要

The present invention is directed to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.

主权项

1. A medical device comprising:
a medical device that is capable of being compacted and expanded; a polymeric substrate material, wherein said polymeric substrate material is fluoropolymeric in composition; a polymeric covering material attached to at least a portion of a surface of said substrate material; a first plurality of heparin molecules having anti-thrombin III binding activity end point attached to at least a portion of said polymeric covering material; and a composition comprising a second plurality of heparin molecules non-covalently combined with said first plurality of heparin molecules;
wherein said first plurality of heparin molecules have an anti-thrombin III binding activity of at least 10 picomoles anti-thrombin III per square centimeter (pmol/cm2) substrate material when measured following compaction of said medical device to 50% of said medical device's original size and expansion of said medical device.