Methylmalonic acid compositions, biological methods for making same, and microorganisms for making same

摘要

Microorganisms and methods are provided for biological synthesis of methylmalonic acid and derivatives thereof. Engineered microorganisms such as bacteria, yeast, and fungi are configured to produce or overproduce methylmalonic acid and/or derivatives thereof. Methods involve the use of such engineered microorganisms to produce methylmalonic acid and/or derivatives thereof from carbon sources. Methods may include production in a fermenter and optional purification of the product.

主权项

1. A non-natural microorganism chosen from archaea, bacteria, yeast or fungus which is engineered to produce or overproduce methylmalonic acid.