| 发明名称 |
RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF |
| 摘要 |
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules. |
| 申请公布号 |
US2016230169(A1) |
申请公布日期 |
2016.08.11 |
| 申请号 |
US201514855091 |
申请日期 |
2015.09.15 |
| 申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
Davidson Beverly L.;Mas Monteys Alejandro;Boudreau Ryan |
| 分类号 |
C12N15/113;C12N15/86;C12N7/00 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated RNA duplex comprising a first strand of RNA and a second strand of RNA, wherein the first strand comprises at least 15 contiguous nucleotides encoded by HDAS 07 (SEQ ID NO:1), HDAS 18 (SEQ ID NO:2), HDAS 19 (SEQ ID NO:3) or HDAS 20 (SEQ ID NO:4), and wherein the second strand is complementary to at least 12 contiguous nucleotides of the first strand. |
| 地址 |
Iowa City IA US |
