| 发明名称 |
Generation of Lineage-Restricted Progenitor Cells from Differentiated Cells |
| 摘要 |
Method for reprogramming differentiated cells into lineage restricted progenitor cells is provided. The method may include contacting differentiated cells with inhibitors of tyrosine phosphatases and apoptosis to de-differentiate differentiated cells into lineage restricted progenitor cells. |
| 申请公布号 |
US2016230144(A1) |
申请公布日期 |
2016.08.11 |
| 申请号 |
US201514868020 |
申请日期 |
2015.09.28 |
| 申请人 |
The Regents of the University of California |
发明人 |
Conboy Irina M.;Paliwal Preeti |
| 分类号 |
C12N5/077;C12N9/16;A61K35/34;G01N33/50 |
主分类号 |
C12N5/077 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for generating lineage-restricted progenitor cells from a differentiated cell, the method comprising:
contacting a differentiated cell with an effective amount of an agent that inhibits tyrosine phosphatases and an effective amount of an agent that inhibits apoptosis under conditions sufficient for generation of lineage-restricted progenitor cells from the differentiated cell, wherein the differentiated cell and the lineage-restricted progenitor cells have the same lineage. |
| 地址 |
Oakland CA US |
