ASSAY FOR THE DETECTION OF THE PHENYLPIPERAZINE FAMILY

摘要

The current invention describes novel immunogens which are used in the production of novel antibodies with unique binding properties in that they cross-react with a variety of phenylpiperazine derivatives. These antibodies enable methods and kits to detect and/or determine phenylpiperazine derivatives (for example mCPP, TFMPP and MeOPP) in an in vitro sample which are advantageous over currently available analytical methods in terms of cost, ease of use, speed and sensitivity.

主权项

1. A hapten of the general structure: wherein, one of X and Y is H and the other is -(A)m-(B)n-D; wherein A is attached to the aromatic ring; wherein A is selected from —C(O)—, O, and NH; wherein m=0 or 1; wherein B is a C1-C10, preferably a C1-C6, substituted or unsubstituted straight or branched chain alkylene moiety or arylene moiety; wherein n=0 or 1; and wherein D is selected from a carboxyl, a dithiopyridyl, a maleimidyl, a hydroxyl, a thiol, and an aldehyde moiety.