Alkadiene derivatives, their preparation, and pharmaceutical compositions containing them

摘要

Substituted alkadienes of the formula: <IMAGE> (I) in which R1 is hydroxy or acetoxy, R2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, and R3 is alkylthio or alkoxy and R4 is naphthoyl or optionally substituted benzoyl, or R3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio, or R3 and R4 form, with the carbon atom to which they are attached, a ring-system of formula: <IMAGE> in which R5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.