| 摘要 |
<p>PURPOSE:To provide the subject new compound having strong platelet- coagulating action and antianginal action and low toxicity, and useful as a preventive and treating agent for circulatory diseases. CONSTITUTION:A prostaglandin I2 compound having a halogen atom on 7-site C atom of natural-type prostaglandin I2 and a cycloalkylene group on the alpha-chain, its ester and its salt expressed by formula I [R<1> is (substituted) 1-10C alkyl, (substituted) 5- or 6-membered cycloalkyl, etc. ; R<2> is H, 1-10C alkyl or cation; one of R<3> and R<4> is H and the other is F or Cl; (k), (l), (m) and (n) are 0-6; 0<=k+n<=4; 1<=l+m<=6], etc., e.g. 2,3-methylene-7alpha-fluoro-17,20- dimethyl PGI2. The compound of formula I can be produced by converting a compound of formula II (R<21> is 1-10C alkyl, etc.; R<31> and R<41> are protecting group other than trimethylsilyl) into the compound of formula III and subjecting the product to fluorination, deprotection and, as necessary, hydrolysis, salt- forming, etc.</p> |
