发明名称 |
Short interfering nucleic acid hybrids and methods thereof |
摘要 |
Disclosed herein are siHybrids used for gene silencing. An siHybrid is a short double-stranded molecule comprised of one strand of DNA and one strand of RNA, annealed together, with a 2-base overhang at each 3' end. In addition to DNA and RNA, it may contain PNA or other nucleic acid analogs. siHybrids can silence a gene with greater magnitude and duration than siRNA. sihybrids are ideal candidates for pharmaceutical and therapeutic agents for treating diseases caused by an over-expressed gene or a cancerous gene. siHybrids can be used as antivirus agents, fungicides, herbicides or pesticides. An appropriate siHybrid can be designed to silence any gene in any eukaryotic cell or organism.
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申请公布号 |
US2006287269(A1) |
申请公布日期 |
2006.12.21 |
申请号 |
US20060434836 |
申请日期 |
2006.05.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CHRISTIAN ALLEN T.;LAMBERTON JANELLE S. |
分类号 |
A61K48/00;C12P19/34;A61K31/7088;C07H21/00;C07H21/02;C07H21/04;C12N15/09;C12N15/11;C12Q;C12Q1/00;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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