发明名称 |
Haemophilus influenzae lipopolysaccharide inner-core oligosaccharide epitopes as vaccines for the prevention of Haemophilus influenzae infections |
摘要 |
The present invention relates to a lipopolysaccharide moiety comprising a conserved triheptosyl inner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extension, and to vaccines obtaines therefrom which are cross-reactive for Haemophilus influenzae strains. The invention also relates to defined mutations in the biosynthetic machinery for lipopolysaccharide (LPS;) expression in Haemophilus influenzae useful to obtain the abovementioned moiety. The invention also relates to using conjugates of the LPS from the mutant strains so obtained to elicit a heterologous immune response against a wide range of disease-causing H. influenzae strains. More specifically, the invention relates to vaccines for prevention of bacterial infections comprising core lipopolysaccharide of Haemophilus influenzae. |
申请公布号 |
US7364739(B2) |
申请公布日期 |
2008.04.29 |
申请号 |
US20040362458 |
申请日期 |
2004.11.01 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA;THE CHANCELLOR, MASTERS, AND SCHOLARS OF THE UNIVERSITY OF OXFORD |
发明人 |
RICHARDS JAMES C.;COX ANDREW;MOXON RICHARD;HOOD DEREK;SCHWEDA ELKE K. H.;MAANSSON MARTIN |
分类号 |
A61K39/00;C12N15/09;A61K39/145;A61K39/395;A61P31/16;C07K16/12;C08B37/00;C12P21/08 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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