PROTEIN VESICLES AND METHODS OF MAKING AND USING THEREOF

摘要

Hollow, protein vesicles are provided. The protein vesicles can be loaded with desired cargo to be delivered to a subject, for example a human. One embodiment provides a protein vesicle made of a protein membrane surrounding a hollow core. The protein membrane includes a first and a second modular protein amphiphile. The first modular protein amphiphile includes a hydrophobic block and a first hydrophilic protein binding block. The second modular protein amphiphile includes a variable polypeptide block and a second hydrophilic protein binding block that binds to the first hydrophilic protein binding block. The first and second protein amphiphiles self-assemble to form the hollow, protein vesicle.

主权项

1. A hollow, protein vesicle comprising:
a protein membrane surrounding a hollow core, wherein the protein membrane comprises a first and a second modular protein amphiphile, wherein the first modular protein amphiphile comprises a hydrophobic block and a first hydrophilic protein binding block and the second modular protein amphiphile comprises a variable polypeptide block and a second hydrophilic protein binding block that binds to the first hydrophilic protein binding block; and wherein the first and second protein amphiphiles self-assemble to form the hollow, protein vesicle.