ATTENUATED GENOTYPE 1 JAPANESE ENCEPHALITIS VACCINE COMPOSITION CONTAINING THE SAME FOR PREVENTING JAPANESE ENCEPHALITIS IN SWINE

摘要

The present invention relates to a vaccine composition including an attenuated genotype 1 Japanese encephalitis virus for the prevention of porcine Japanese encephalitis. Specifically, the present invention relates to a novel virus strain obtained by serially injecting various cell strains with a genotype 1 Japanese encephalitis virus KV1899; and to a live vaccine strain which contains the virus strain and thus can secure excellent stability and immunogenicity. In the case of using a live vaccine containing a virus strain KV1899-120P provided according to the present invention, the live vaccine can highly effectively generate an antibody against a genotype 1 Japanese encephalitis virus in the human body, and thus can prevent infection. Especially, the live vaccine can prevent infection in pigs which are amplifying hosts of Japanese encephalitis viruses, and thus can greatly reduce the risk of Japanese encephalitis virus infection in humans.