Methods and Materials for the Production of Monomers for Nylon-4/Polyester Production

摘要

This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.

主权项

1. A non-naturally occurring method of producing 1,4-butanediol, said method comprising enzymatically converting 4-hydroxybutyrate to 1,4 butanediol using a carboxylate reductase and an alcohol dehydrogenase.