发明名称 |
Biodegradable lipids for the delivery of active agents |
摘要 |
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. |
申请公布号 |
AU2011261247(B2) |
申请公布日期 |
2016.08.25 |
申请号 |
AU20110261247 |
申请日期 |
2011.06.03 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
MANOHARAN, MUTHIAH;MAIER, MARTIN;JAYARAMAN, MUTHUSAMY;MATSUDA, SHIGEO;JAYAPRAKASH, NARAYANANNAIR K.;RAJEEV, KALLANTHOTTATHIL G.;AKINC, AKIN;BAILLIE, THOMAS A. |
分类号 |
C07C69/02;A61K9/10;A61K39/00;A61K47/48;A61K48/00;C07C211/62;C07C211/63;C12N15/87 |
主分类号 |
C07C69/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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