METHOD OF PRODUCING TYLOSIN DERIVATIVES

摘要

NEW MATERIAL:A compound shown by the formulaI[R1 is amino, mono-, or di-lower alkylamino, a group shown by the formula II (n is 2-20); R2 is H or OH; R3 is aldehyde group which may have a protecting group]. EXAMPLE:23-Deoxy-23-ethylamino mycaminosyl tylonolide shown by the formula III. USE:An antibacterial agent. Having high antibacterial power than tylosin, mycaminosyl tylonolide, etc. A dose of 10-1,000mg/time is medicated orally(parenterally). PROCESS:A compound shown by the formula IV (R3' is an aldehyde group with a protecting group; X is halogen) is reacted with a compound shown by the formula R1-X (e.g., ethylamine, etc.) in an organic solvent such as preferably THF, etc., and, if necessary, the aldehyde-protecting group is eliminated.