| 摘要 |
<p>NEW MATERIAL:A compound of formula I [A-G are each O, S, CO, CHR<a>, CR<b> or NR<c> (R<a>-R<c> are each H or alkyl); H is CO, CHR<d> or CR<e> (R<d> and R<e> are each H or alkyl); R is 5- or 6-membered heterocycle having 1-4 heteroatom(s); R<1> is H, alkyl, alkenyl, etc.; R<2>-R<5> are each H, halogen or alkyl; R<6> and R<7> are each F, CF3 or alkyl; R<8> is H, F, CF3, alkyl, alkoxy, etc.] or its salt. EXAMPLE:(E)-N-ethyl-N-(6,6-dimethyl-4-heptynyl)-2-{2-[3-(3-thienyl)-2- propenyloxy]ethyloxy}ethylamine. USE:A therapeutic or preventive agent for hypercholesterolemia, hyperlipemia and arteriosclerosis. PREPARATION:For example, an amine of formula II is reacted with equimolar or a bit excess amount of an alkylating agent of formula III to obtain the objective compound of the formula I.</p> |
