| 摘要 |
<p>A trialkylamine derivative represented by general formula (1) or a pharmacologically acceptable salt thereof, wherein R?1 and R2¿ may be the same or different from each other and each represents lower alkyl; R?3, R4 and R5¿ may be the same or different from one another and each represents hydrogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl or halogen; R?6 and R7¿ may the same or different from each other and each represents hydrogen or lower alkyl; R8 represents hydrogen, lower alkyl, lower alkoxy or halogen; X represents oxygen, sulfur, -CH=N- or -CH=CH-; Y represents oxygen, sulfur, methylene, =N-R11 (wherein R11 represents lower alkyl), =SO or =SO¿2?; Z represents -OCO(CH2)p∩ or -OCH2(CH2)p∩ (wherein p represents a number of 0 to 4 and symbol ∩ represents the linkage with a benzene ring; and m and n represent each a number of 0 to 3 and the sum of m and n is 3 or less, provided that the case where m is 0, n is 1 or 2, R?1 and R2¿ represent each methyl, X represents -CH=CH-, Y represents -CH¿2?-, and Z represents -O-CO∩ is excluded). These compounds have an excellent activity of ameliorating digestive tract movement and hence are widely utilized in the treatment of digestive system diseases.</p> |
