| 摘要 |
Constructs coding for NLS-GHBP are claimed. Also transgenic non-human animals expressing NLS-GHBP are claimed, and a method for producing such animals comprising introducing a NLS-GHBP expression plasmid into the pronucleus of a fertilised ovum, transferring the ovum to the reproduction tract of a recipient animal, letting the ovum develop, analysing the resulting offspring and identifying transgenic animals in which the NLS-GHBP expression plasmid have been integrated. Transgenic agricultural animals expressing NLS-GHBP produce more milk and/or meat than non-transgenic animals. The constructs and transgenic animals as well as tissue, cell cultures and derived from such animals are suitable models for the study of disorders affecting systems dependent on signal transduction through the JAK-STAT pathway, and also for screening compounds for treatment of such disorders. Substances that upon administration stimulate the interaction between GHBP and intracellular signalling molecules, simulate GHBP in interaction with intracellular signalling molecules, or lead to intracellular production of growth hormone binding protein are also claimed. |
