Production of racemic amine compounds comprises gas phase catalytic racemization of an optically active amine in presence of hydrogen, useful as pharmaceuticals and intermediates for active substances

摘要

Gas phase racemisation of an optically active amine uses a hydrogenation or dehydrogenation catalyst in the presence of hydrogen at an elevated temperature. Production of racemic amines (I) comprises racemisation of a corresponding optically active amine by reaction with a hydrogenation or dehydrogenation catalyst in the presence of hydrogen at an elevated temperature in the gas phase. R<1> , R<2> = different and are alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heterocyclyl, all optionally substituted by Q; provided that R<1> and R<2> = different; R<3> = H or alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heterocyclyl, all optionally substituted by Q; Q = alkyl, cycloalkyl, alkoxy, aryloxy, NH2, NH(alkyl) or N(alkyl)2.