The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39 - 42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonists.
申请公布号
US7307142(B2)
申请公布日期
2007.12.11
申请号
US20040996607
申请日期
2004.11.26
申请人
YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM;UNIVERSITES PARIS 6 ET PARIS 7;INSTITUT NATIONALE DE LA RECHERCHE AGRONOMIQUE (INRA)