HETEROCYCLIC COMPOUNDS POSSESSING ELASTASE-INHIBITORY ACTIVITY AND THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITION AND AGENT BASED ON THEREOF

摘要

FIELD: organic chemistry, biochemistry. ^ SUBSTANCE: invention describes heterocyclic compounds represented by the general formula (I): and possessing elastase-inhibitory activity, and intermediate compounds for synthesis of such compounds. In the formula (I) R1 represents heterocyclic group represented by the formula (II): wherein A represents presence or absence of benzene ring; X represents oxygen atom, sulfur atom or -NH; Y represents nitrogen atom or -CH. Indicated heterocyclic group can be substituted with 1-3 substitutes that can be similar or different and they are chosen from group consisting of lower alkyl, lower alkoxy group and phenyl that can be optionally substituted with halogen-containing lower alkyl, lower alkoxy group or halogen atom; each among R2 and R3 represents hydrogen atom or hydroxyl, or R2 and R3 can be combined to form oxo group under condition that both are not hydrogen atoms. ^ EFFECT: valuable biochemical property of compounds. ^ 8 cl, 7 tbl