| 摘要 |
<p>The present invention provides, in part, methods for treating a tumor in a human subject comprising inhibiting IGF-1 receptor signaling, methods of d etermining whether a tumor is more or less likely to respond to such treatme nt, and compositions for practicing such methods. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R anti bodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of s uch antibodies, and IGF-1R-binding polypeptides comprising such fragments. O ther embodiments provide nucleic acids encoding such antibodies, antibody fr agments and derivatives and polypeptides, cells comprising such polynucleoti des, methods of making such antibodies, antibody fragments and derivatives a nd polypeptides, and methods of using such antibodies, antibody fragments an d derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.</p> |
