IMMUNOTHERAPEUTIC METHOD FOR TREATING PANCREATIC CANCER

摘要

The invention relates to treatment of pancreatic cancer and metastases thereof. More specifically, the invention relates to immunogenic polypeptides comprising at least a portion of a pancreatic tumor cell-associated protein or immunologically active variants thereof and to nucleic acids encoding such polypeptides and to the use thereof in immunotherapeutic methods of treatment of pancreatic cancer. Said immunogenic polypeptides are provided by the zona pellucida (ZP) (glyco)proteins. ZP (glyco)proteins and fragments thereof that can induce a CD8+ and/or CD4+ T cell response as well as nucleic acid sequences encoding them can suitably be used in the present immunotherapeutic strategies.