| 主权项 |
1. A compound of the formula in which R1 is a group of the formula where # is the attachment site to the nitrogen atom,R6 is 5-membered heteroaryl,
where heteroaryl may be substituted by a substituent selected from the group consisting of oxo, chlorine, cyano, hydroxyl and C1-C3-alkyl,
in which alkyl may be substituted by 1 to 3 substituents selected independently from the group consisting of hydroxyl, amino, hydroxycarbonyl and methoxy, orin which alkyl may be substituted by 1 to 7 fluorine substituents, orin which alkyl is substituted by a substituent selected from the group consisting of hydroxyl, amino, hydroxycarbonyl and methoxy, and in which alkyl is additionally substituted by 1 to 6 fluorine substituents,R7 is hydrogen, fluorine or chlorine,R8 and R9 together with the carbon atoms to which they are bonded form a 5-membered heterocycle,
where the heterocycle may be substituted by 1 to 2 substituents selected independently from the group consisting of oxo, chlorine, cyano, hydroxyl, C1-C3-alkyl, pyrazolyl and pyridyl,
in which alkyl may be substituted by 1 to 3 substituents selected independently from the group consisting of hydroxyl, amino, hydroxycarbonyl and methoxy, orin which alkyl may be substituted by 1 to 7 fluorine substituents, orin which alkyl is substituted by a substituent selected from the group consisting of hydroxyl, amino, hydroxycarbonyl and methoxy, and in which alkyl is additionally substituted by 1 to 6 fluorine substituents,R10 is hydrogen, fluorine or chlorine, R2 is hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl, 4- to 9-membered heterocyclyl bonded via a carbon atom or 5- or 6-membered heteroaryl,
where alkyl may be substituted by 1 to 2 substituents selected independently from the group consisting of fluorine, hydroxyl, amino, hydroxycarbonyl, C1-C3-alkylamino, difluoromethyl, trifluoromethyl, —(OCH2CH2)n—OCH3, —(OCH2CH2)m—OH, trimethylaminium and pyrrolidinyl,
in which n is a number from 1 to 6,in which m is a number from 1 to 6, andwhere cycloalkyl may be substituted by 1 to 2 substituents selected independently from the group consisting of oxo, fluorine, hydroxyl, amino, C1-C4-alkyl, C1-C3-alkylamino and morpholinyl,
in which alkyl and alkylamino may be substituted by 1 to 5 fluorine substituents, andwhere heterocyclyl may be substituted by 1 to 2 substituents selected independently from the group consisting of oxo, fluorine, hydroxyl, amino, hydroxycarbonyl, C1-C4-alkyl, C1-C3-alkylamino, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroeth-1-yl, C1-C4-alkoxycarbonyl, aminocarbonyl and C1-C3-alkylaminocarbonyl,
where alkyl and alkylamino may be substituted by 1 to 5 substituents selected independently from the group consisting of hydroxyl and fluorine, andwhere heterocyclyl may additionally be substituted by 1 to 4 substituents selected independently from the group consisting of fluorine and methyl, andwhere heteroaryl may be substituted by 1 to 2 substituents selected independently from the group consisting of oxo, chlorine, cyano, hydroxyl and C1-C3-alkyl, R3 is hydrogen or C1-C3-alkyl, or R2 and R3 together with the nitrogen atom to which they are bonded form a 4- to 7-membered heterocycle,
where the heterocycle may be substituted by 1 to 2 substituents selected independently from the group consisting of oxo, fluorine, hydroxyl, amino, hydroxycarbonyl, C1-C4-alkyl, C1-C3-alkylamino, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroeth-1-yl, C1-C4-alkoxycarbonyl, aminocarbonyl and C1-C3-alkylaminocarbonyl, R4 is hydrogen, fluorine, chlorine, methyl or methoxy, R5 is hydrogen, fluorine, chlorine, C1-C4-alkyl, methoxy or trifluoromethyl, or one of the salts thereof, solvates thereof or solvates of the salts thereof. |
