| 摘要 |
<p>1522735 Implantable pellets SYNTEX (USA) INC 23 April 1976 [28 April 1975] 16692/76 Heading A5B A solid spherical subcutaneously implantable pellet which exhibits a substantially constant rate of release of active agent over a first time period and an abrupt termination of drug release at the end of the time period comprises (a) a bicompatible, inert, spherical' core having a diameter of about 2 mm to about 10 mm and (b) at least one bicompatible bisoluble coating having a substantially uniform thickness of about 0.05 mm to about 1.0 mm intimately adhering to and completely covering the inert core, the composition of the coating comprising a substantially homogeneous mixture of (i) about 5% to about 90% weight of a pharmaceutically suitable carrier and (ii) about 10% to about 95% weight of a biologically active agent.</p> |
