| 发明名称 |
2-beta,19-ethylene bridged steroids as aromatase inhibitors. |
| 摘要 |
<p>The present invention is directed to a group of androstane compounds which contain an ethylene radical bridging the 2- and 19-positions. These compounds are useful as aromatase inhibitors and they are prepared by the cyclization of a 19-[2-(4-toluenesulfonyloxy)ethyl]androst-4-ene-3,17-dione using a strong base.</p> |
| 申请公布号 |
EP0488383(A1) |
申请公布日期 |
1992.06.03 |
| 申请号 |
EP19910120560 |
申请日期 |
1991.11.29 |
| 申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
JOHNSTON, J. O'NEAL;PEET, NORTON P.;BURKHART, JOSEPH P. |
| 分类号 |
A61K31/565;A61P5/32;A61P15/16;A61P15/18;A61P35/00;A61P43/00;C07J1/00;C07J53/00 |
主分类号 |
A61K31/565 |
| 代理机构 |
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