发明名称 |
DNA REGULATORY ELEMENTS RESPONSIVE TO CYTOKINES |
摘要 |
The present invention provides oligonucleotides sequences comprising DNA regulatory elements comprising point mutations of Ly6E GAS element that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonists and antagonists of gene transcription. |
申请公布号 |
EP0755453(A1) |
申请公布日期 |
1997.01.29 |
申请号 |
EP19950916343 |
申请日期 |
1995.04.10 |
申请人 |
LIGAND PHARMACEUTICALS, INC. |
发明人 |
LAMB, I. PETER;SEIDEL, H. MARTIN |
分类号 |
G01N33/50;C12N5/10;C12N15/09;C12N15/85;C12Q1/25;C12Q1/68;C12Q1/70;G01N33/53;G01N33/566 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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