发明名称 |
A method for quantification of stratum corneum hydration using diffuse reflectance spectroscopy |
摘要 |
An apparatus and method for non-invasively quantifying the hydration of the stratum corneum of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting NIR absorption spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, a calibration model developed from an exemplary set of measurements is applied to predict the SC hydration for the sample. The method of SC hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. The stratum corneum hydration measurement is therefore suitable for further spectral analysis and the quantification of biological and chemical compounds, such as blood analytes. |
申请公布号 |
AU9064001(A) |
申请公布日期 |
2002.04.08 |
申请号 |
AU20010090640 |
申请日期 |
2001.09.05 |
申请人 |
INSTRUMENTATION METRICS, INC. |
发明人 |
BRIAN J. WENZEL;STEPHEN L. MONFRE;TIMOTHY L. RUCHTI;KEN MEISSNER;FRANK GROCHOCKI;THOMAS B. BLANK;JESSICA RENNERT |
分类号 |
G01N21/35;A61B5/00;A61B5/103;A61B5/107;A61B5/145;A61B5/1455;A61B5/1495;G01N21/27;G01N21/47;G01N21/49;G06F19/00 |
主分类号 |
G01N21/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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