1,2,5,10-tetrahydropyridazino(4,5-b)quinoline-1,10-diones and their use for the treatment of pain

摘要

Compounds according to structural diagram (I) are disclosed, wherein R¹, A, E and D are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (I). The following is an examiner's statement of reasons for allowance: In view of applicants' amendments to the claims which limit "E" to phenyl or cycloalkyl groups the rejections of the previous action no longer pertain as they at best teach "E" as alkyl.