HAIR GROWTH STIMULATING AGENT CONTAINING CYCLOSPORINE 7-THIOAMIDE DERIVATIVE AS AN ACTIVE INGREDIENT

摘要

PURPOSE: A hair growth stimulating agent containing cyclosporine 7-thioamide derivative as an active ingredient is provided, thereby the hair growth can be effectively stimulated. CONSTITUTION: The hair growth stimulating agent contains cyclosporine 7-thioamide represented by formula(1) as an active ingredient, in which A is N-methyl-(4R)- 4-((E)-2-butenyl)- 4-methyl-L-threonine, (2S, 3R, 4R, 6E)-3 -sulfhydryl-4- methyl-2- (methylamino)-6- octenoic acid, or (2S, 4R, 6E)-3-oxo-4- methyl-2- (methylamino)-6- octenoic acid; B is L-alanine, L-threonine, L-valine or L-norvaline; C is Sarcosine, D-methylalanine, D-2-(methyl amino) pent-4-enoyl, D-2-(methyl amino) pent-4-ynoyl, or D-Sar(2-SMe); D is N-methyl-L-leucine, gamma-hydroxy N-methyl L-leucine or L-valine; E is L-valine or L-norvaline; F is N-methyl-L-leucine, gamma-hydroxy N-methyl L-leucine or L-leucine; Alathio is L-alanine thioamide; G is D-alanine or D-serine; H is N-methyl L-leucine, gamma-hydroxy-N-methyl L-leucine or L-leucine; I is N-methyl L-leucine, gamma-hydroxy-N-methyl-L-leucine or L-leucine; and J is N-methyl-L-valine or L-valine.