METHOD FOR DETERMINATION OF TENDENCY TO PROGRESS TO APOPTOSIS AND USE OF THE SAME

摘要

Disclosed is an effective method for the diagnosis of Alzheimer disease. The method comprises detecting the amount of ATBF1 in pyramidal cells of the hippocampus to be tested which have been isolated from a living body (in the case of autopsy, a dead body) and then determining whether or not the pyramidal cells progress to the neuronal death using the results of the detection. In a preferred embodiment, the localization of a given ATBF1 fragment produced by post-translational processing is detected to determine whether or not pyramidal cells of the hippocampus to be tested progress to the neuronal death.