发明名称 |
COMPOUNDS TO FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR3) AND THERAPEUTIC USES |
摘要 |
The invention provides conjugates that consist of a drug moiety agent and a cell binding agent that target human fibroblast growth factor receptor 3 (FGFR3). These conjugates have therapeutic use as they are designed and tailored to target a specific cell population and deliver a powerful cytotoxin inside the cell. The conjugate of the present invention has significant advantages over other conjugates known in the art by providing a targeted tumor therapy as well as bystander activity to neighboring cells in an important oncology receptor that is only moderately expressed. |
申请公布号 |
AP201609271(D0) |
申请公布日期 |
2016.06.30 |
申请号 |
AP20160009271 |
申请日期 |
2014.12.11 |
申请人 |
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发明人 |
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分类号 |
C07K16/28;A61K31/559;A61K47/48;A61P35/00;G01N33/574 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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