| 摘要 |
1. An anthracycline glycoside of formula I wherein the wavy line means that the hydroxy group at 13-position may be at α or β position, or a mixture thereof. 2. A compound according to claim 1 which is 4-demethoxy-13 (S/R) dihydro-3'-deamino-3'-aziridinyl-4'-methansulfonyl daunorubicin, 4-demethoxy-13(S) dihydro-3'-deamino-3'-aziridinyl-4'-methansulfonyl daunorubicin or 4-demethoxy-13(R) dihydro-3'-deamino-3'-aziridinyl-4'-methansulfonyl daunorubicin. 3. A process for the preparation of an anthracycline glycoside of formula (I) as defined in claim 1, which process comprises reducing the anthracycline of the formula II in presence of a reductive agent in a mixture of organic solvents and, if desired and necessary, separating the resultant mixture of 13(R) and 13(S) compounds into the single diastereoisomer. 4. The process according to claim 3, in which the reductive agent is sodium borohydride. 5. The process according to claims 4, in which the reduction is carried out at a temperature below 50 degree C. 6. The process according to claims 6 in which the reduction is carried out at a temperature of -70 degree C. 7. A pharmaceutical composition comprising an anthracycline glycoside of formula I as defined in claim 1, and a pharmaceutically acceptable carrier or diluent. 8. Use of the compound as defined in claim 1 or 2 for treating a human or an animal organism conservatively. 1. A herbicidal composition comprising molinate and oxyfluorfen in a weight ratio of from about 500:1 to about 30:1. 2. A herbicidal composition according to claim I in which the weight ratio is from about 250:3.25 to about 5:1. 3. A herbicidal composition according to claim I in which the weight ratio is from about 250:1 to about 40:1. 4. A herbicidal composition according to claim 1 which is liquid. 5. A herbicidal composition according to claim 1 which is solid. 6. A herbicidal composition according to claim 1 characterized by a controlled release of active substances. 7. A herbicidal composition according to claim 6 in which at least one of molinate and oxyfluorfen is contained in microcapsules. 8. A method of controlling weeds in the presence of a rice crop comprising applying to said crop, said weeds, or the locus of said crop and/or said weeds, a herbicidally-effective amount of a composition according to any of claims 1 to 7. |
