| 摘要 |
NEW MATERIAL:A compound expressed by the formula: [R1-R6 is substituent group, at least one of R1-R6 is hydrophilic polymer (derivative), at least one of the rest is treating bioactive substance (derivative) and when the total of those substituent groups is <=5, the rest is -OR7, -NHR8, -NH9R10, -R11 or X (OR7 is tyrosine residue, R7 is alkoxy of 1-24C alkyl; -NHR8 is amino acid residue or amino wherein R8 is 1-24C alkyl; R9, R10 is 1-24C alkyl; R11 is 1-24C alkyl; X is halogen)]. EXAMPLE:A monomethoxy polyethylene glycol glycine ethyl esterified cyclotriphosphazene-SOD. USE:A bioactive substance for treating animal disease. PREPARATION:A hydrophilic polymer is reacted with a hexahalogenized cyclotriphosphazene in a solvent, recrystallized and subjected to gel filtration. |
