| 摘要 |
PURPOSE: To nitrate acetophenone derivative useful as an intermediate for organic chemicals such as pharmaceuticals in high reaction rate and yield by using an extremely small amount of a metal and/or a metal compound or an inorganic acid. CONSTITUTION: (A) An acetophenone derivative the formula (R<1> to R<3> are each H or a halogen; at least one of R<1> to R<3> is a halogen; R<4> is H, a halogen, an alkyl, amino or an alkoxy; (n) is 1-4) (e.g. acetophenone) is nitrated with (B) oxygen or air containing a nitrogen oxide and ozone by using a catalyst consisting of (C) a metal (preferably at least one kind of metal selected from among transition metals, tin, antimony, lead and bismuth, especially iron) and/or a compound of the metal or (D) an inorganic acid (preferably sulfuric acid and/or sulfur trioxide).
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