发明名称 |
Dimeric arylisoquinoline alkaloids and derivatives thereof |
摘要 |
The present invention provides new naphthylisoquinoline derivatives. In particular, the present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers. Monomeric and dimeric compounds of the present invention have medically useful properties, such as antimicrobial properties, more specifically such as antimalarial and antiviral properties. Monomeric compounds of the present invention are also useful as building blocks or intermediates for synthesis of novel dimeric arylisoquinoline alkaloids. Monomeric and dimeric compounds of the present invention may be obtained in substantially pure form by total synthesis, partial synthesis, or derivatization from known synthetic or naturally occurring compounds, and by isolation and purification from plants of the Dioncophyllaceae and Ancistrocladaceae families.
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申请公布号 |
US6331630(B1) |
申请公布日期 |
2001.12.18 |
申请号 |
US20000527002 |
申请日期 |
2000.03.16 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BRINGMANN GERHARD;BOYD MICHAEL R.;WENZEL MATTHIAS |
分类号 |
A61K31/47;A61K31/4725;A61P33/06;C07D217/02;C07D217/04;C07D217/24;C07D401/04;C07D401/10;C07D491/04;(IPC1-7):C07D401/10;A61K31/472 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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