发明名称 |
VIRAL VECTORS FOR THE TREATMENT OF DIABETES |
摘要 |
They are provided gene constructs comprising a nucleotide sequence encoding the Insulin-like growth factor 1 (IGF-1) of a mammal; and target sequences of a microRNA of a tissue where the expression of IGF-1 is wanted to be prevented, wherein the sequences (a) and (b) are operationally linked to a promoter of ubiquitous expression. Also provided are expression vectors comprising the gene construct and pharmaceutical compositions comprising them. They are useful in the treatment and/or prevention of diabetes mellitus in mammals, wherein a dysfunction and/or a loss of the beta-cells of the islets of Langerhans is present. |
申请公布号 |
WO2016087678(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
WO2015EP78878 |
申请日期 |
2015.12.07 |
申请人 |
UNIVERSITAT AUTÒNOMA DE BARCELONA |
发明人 |
MALLOL DOMÍNGUEZ, CRISTINA;BOSCH TUBERT, FÀTIMA;JIMÉNEZ CENZANO, VERÓNICA |
分类号 |
C12N15/86;A61K48/00;C07K14/65 |
主分类号 |
C12N15/86 |
代理机构 |
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主权项 |
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地址 |
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