| 摘要 |
A system and corresponding method for detecting cell apoptosis includes a laser source configured to apply an incident excitation wavelength to a biological sample. The wavelength is in resonance with a heme group. A detector is configured to detect inelastic light scattering resulting from a vibrational mode of cytochrome b or cytochrome c. A processor is configured to monitor the biological sample based on the light scattering for a change of cytochrome b state or an increase in cytochrome c in a folded state in solution relative to cytochrome c in an unfolded state in a mitochondrial membrane to detect initiation of apoptosis. The laser source and detector can be mounted within a patch and applied to a person. Embodiments provide for convenient monitoring of tissue health, determination of efficacy of stimulants for inducing apoptosis in cells in research, and early detection of cell apoptosis. |
