发明名称 |
Compact member, method of manufacturing and use thereof |
摘要 |
The invention relates to a compact member comprising a plurality of porous cellulose matrices (PCMs), and providing extended release of an active compound located in the pores of said PCMs together with a release modifying agent. The friability of the compact member is less than 2.1%, and the disintegration time in-vitro of said compact member is less than 240 minutes. The compact member is manufactured by exposing a plurality of PCMs to an active compound and a release modifying agent, in optional sequence or mixture, for a time sufficient for said active compound and release modifying agent to fill the pores in said PCMs to a preselected level. The PCMs are sub-sequently compacted to a desired shape. The invention further relates to use of the compact members for administration of a drug.
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申请公布号 |
US2002028245(A1) |
申请公布日期 |
2002.03.07 |
申请号 |
US20010962640 |
申请日期 |
2001.09.25 |
申请人 |
GREN TORKEL;NYSTROM CHRISTER |
发明人 |
GREN TORKEL;NYSTROM CHRISTER |
分类号 |
A61K;A61K9/16;A61K9/20;A61K9/22;A61K47/38;(IPC1-7):A61K9/20 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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