METHOD OF PREPARING GROWTH HORMONE OR GROWTH HORMONE DERIVATIVE CRYSTALS, HUMAN GROWTH HORMONE OR HUMAN DERIVATIVE GROWTH HORMONE CRYSTALS AND PHARMACEUTICAL PREPARATION

摘要

FIELD: biochemistry, endocrinology. SUBSTANCE: invention relates to method of preparing growth hormones or growth hormone derivatives, human growth hormone or their derivative crystals and pharmaceutical preparation as pharmaceutically acceptable growth hormone crystal suspension. Growth hormone crystals are grown in solution containing an organic solvent or combination of organic solvents in the presence of zinc cations at pH solution 5.0-6.8 and temperature 0-30 C. Grown crystals are isolated by the known methods. Grown growth hormone crystals has zinc cations preferably at molar ratio 0.2-10. EFFECT: improved method of preparing. 22 cl, 2 tbl/