RETROVIRAL VECTORS, METHODS FOR THEIR PREPARATION AND THEIR USE FOR GENE TRANSFER INTO CD4-POSITIVE CELLS

摘要

The invention relates to the production and use of retroviral vectors for celltype specific gene transfer, specially to a production method of retroviral vectors containing capsid particles of murine leukemia virus (MLV) and envelope proteins of human immunodeficiency viruses (HIV) or simian immunodeficiency viruses (SIV). Said vectors can be used for gene transfer in selected cell types, specially in CD4-positive mammal cells.