发明名称 |
MATERIALS AND METHODS RELATING TO THE INCREASE IN PROTEIN ACTIVITY |
摘要 |
The invention provides a protein framework which allows active polypeptides e.g. ligands or antigens to be displayed at increased concentration. The inventors show that the lectin binding domains of collectins can be replaced by a polypeptide of interest and that polypeptide can be multimerised by the framework of the collectin and as a result displayed in greater number on a single structure. The inventors show that the activity of polypeptides such as those of the TNF superfamily are significantly enhanced when displayed in this way.
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申请公布号 |
WO0200893(A1) |
申请公布日期 |
2002.01.03 |
申请号 |
WO2001GB02810 |
申请日期 |
2001.06.25 |
申请人 |
CANCER RESEARCH VENTURES LIMITED;AL-SHAMKHANI, AYMEN;GLENNIE, MARTIN |
发明人 |
AL-SHAMKHANI, AYMEN;GLENNIE, MARTIN |
分类号 |
A61K38/00;A61K38/11;A61K38/19;C07K14/705;(IPC1-7):C12N15/62;C07K14/785;C12N5/10;A61K38/18 |
主分类号 |
A61K38/00 |
代理机构 |
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