发明名称 |
Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use |
摘要 |
A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise a naturally occurring amino acid and is covalently bonded to A and P in a regiospecific manner, and P represents a monomer, homopolymer or heteropolymer comprising at least one nucleotide or an analogue thereof, which inhibits the intracellular biosynthesis of nucleotides or nucleic acids in a sequence-independent manner, wherein either or both of the covalent bond between A and L and the covalent bond between L and P can be cleaved intracellularly; a composition comprising such a conjugate; and a method of inhibiting abnormal cellular proliferation in a mammal; and a method of inhibiting replication of a virus in a mammal.
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申请公布号 |
US7262177(B2) |
申请公布日期 |
2007.08.28 |
申请号 |
US20050152135 |
申请日期 |
2005.06.13 |
申请人 |
CELL WORKS THERAPEUTICS, INC. |
发明人 |
TS'O PAUL O. P.;DUFF ROBERT;DEAMOND SCOTT |
分类号 |
A01N43/04;A01N37/18;A61K31/7072;A61K31/715;A61K38/00;A61K47/48;A61P1/16;A61P31/12;A61P31/14;A61P31/20;A61P35/00;C07K9/00 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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