| 发明名称 |
A SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVE, PHARMACEUTICALCOMPOSITIONS MADE THEREFROM |
| 摘要 |
7- (1, 1-Dimethylethyl)-6-(2-ethyl- 2H- 1, 2, 4- triazol- 3-ylmethoxy) -3- ( 2- fluorophenyl) - 1,2,4-triazolo[4,3-b]pyridazine, and pharmaceutically acceptable salts thereof, are selective ligands for GAB A A receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
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| 申请公布号 |
CA2335328(C) |
申请公布日期 |
2007.11.27 |
| 申请号 |
CA19992335328 |
申请日期 |
1999.06.15 |
| 申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
COWDEN, CAMERON JOHN;CASTRO PINEIRO, JOSE LUIS;DAVIES, ANTONY JOHN;MCCABE, JAMES FRANCIS;MADIN, ANDREW;STREET, LESLIE JOSEPH;PEARCE, GARETH EDWARD STEPHEN;CARLING, WILLIAM ROBERT |
| 分类号 |
C07D487/04;A61K31/50;A61K31/5025;A61P25/00;A61P25/22 |
主分类号 |
C07D487/04 |
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