METODO DE TRATAMIENTO DEL CANCER DE PIEL USANDO COMPOSICIONES QUE COMPRENDEN UN INHIBIDOR DEL RECEPTOR DE ENDOTELINA B.

摘要

Described herein are results which show that an endothelin receptor antagonist, BQ788, increases pigmentation and significantly reduces the viability of 7 human melanoma cell lines in culture. Moreover, it is described herein that administration of BQ788 significantly slows melanoma tumor growth in nude mice, including a complete growth arrest in half of the mice treated systemically. Thus, inhibitors of endothelin receptor activity are described herein as beneficial for the treatment of cancer.