发明名称 |
Method of treating pulmonary disease by administering an antibody to G-CSF |
摘要 |
The present invention relates generally to a method for treating or preventing or otherwise ameliorating the effects of pulmonary diseases characterized by or associated with infiltration of neutrophils and complications arising therefrom. The present invention further provides agents and pharmaceutical compositions comprising agents which inhibit the activity of G-CSF or its receptor, interfere with G-CSF signaling and/or which down-regulate expression of G-CSF or its receptor. |
申请公布号 |
US9376682(B2) |
申请公布日期 |
2016.06.28 |
申请号 |
US201314042931 |
申请日期 |
2013.10.01 |
申请人 |
CSL LIMITED |
发明人 |
Crump David Eric;Nash Andrew Donald |
分类号 |
A61K39/395;C12N15/113;A01K67/027;C07K14/535;C07K16/24;A61K38/17;A61K45/06;C07K16/22;C07K16/28;A61K48/00;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
Scully Scott Murphy & Presser |
代理人 |
Scully Scott Murphy & Presser |
主权项 |
1. A method for treating chronic obstructive pulmonary disease (COPD) in a subject, said method comprising administering to said subject a G-CSF-specific antibody or a G-CSF-binding fragment of the antibody in an amount sufficient to reduce one or more symptoms of COPD in said subject, wherein the one or more symptoms are selected from the group consisting of increased neutrophil infiltration, increased neutrophils in bronchoalveolar lavage fluid (BALF), increased neutrophils in sputum, declining lung function, and increased levels of serine proteases. |
地址 |
Parkville AU |