| 发明名称 |
Protective vaccine based on <i>Staphylococcus aureus </i>SA2493 protein |
| 摘要 |
The present invention relates to methods of inducing an immune response to Staphylococcus comprising administering a composition comprising an SA2493-related polypeptide from Staphylococcus aureus as well as derivatives or fragments thereof. The present invention also encompasses methods of treating and/or reducing the likelihood of a Staphylococcus infection by administering a composition comprising an SA2493-related polypeptide or an antibody that specifically binds to an SA2493 polypeptide, derivative or fragments thereof. Compositions administered in the methods of the invention can include one or more additional antigens including, but not limited to, IsdB. Compositions used to practice the methods of the invention are also encompassed. |
| 申请公布号 |
US9376487(B2) |
申请公布日期 |
2016.06.28 |
| 申请号 |
US201314413939 |
申请日期 |
2013.07.09 |
| 申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
McNeely Tessie B.;Cope Leslie;Pancari Gregory D.;Joshi Amita |
| 分类号 |
A61K39/085;C07K16/12;C07K14/31;A61K39/00 |
主分类号 |
A61K39/085 |
| 代理机构 |
|
代理人 |
Fuentas Gloria;Wu Henry P. |
| 主权项 |
1. A method of inducing a protective immune response in a patient against an S. aureus infection comprising the steps of administering to the patient an immunologically effective amount of a composition comprising an immunologically effective amount of a polypeptide of SEQ ID NO:2 and a pharmaceutically acceptable carrier. |
| 地址 |
Rahway NJ US |
